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Dysfunctional hypothalamic function can be seen in ME/CFS patients in the form of up-regulation of hypothalamic 5-hydroxytryptamine (5-HT) receptors (441) and abnormal arginine/vasopressin responses to deprivation tests and water loading (440)

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The average of seven RCTs showed a decrease of 3.54 mg/dL (9 nmol/L).[ref] While a small reduction, it may be significant when combined with other interventions.[ref] Related article: CoQ10: background science, mitochondrial energy, and genetic variants Niacin: Vitamin B3 niacin has been used for decades to lower the risk of heart disease

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