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Among the vitamin E isoforms, the -tocopherol, has other different properties independently from its antioxidant ability: it can inhibit the activity of protein kinase C, reducing the proliferation of different cell types (vascular smooth muscle cells, mesangial cells, neutrophils, monocytes/macrophages, fibroblast, and various cancer cell lines) and the 5-lipoxygenase pathway, inhibiting the release of proinflammatory cytokine IL-1

have shown that MZB display increased sensitivity to lipid peroxidation in Gpx4 -deficient mice 33

The heat stress transcription factor HsfA2 serves as a regulatory amplifier of a subset of genes in the heat stress response in Arabidopsis