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In a previous report, Kudo and colleagues demonstrated that only meningiomas exhibit extremely high GSH levels, in contrast to other forms of brain tumors, such as GBM, gliomas, germinoma, multiple myeloma, and small-cell carcinoma [45]

Consistent with this pattern, the OMe derivative 9 had activity that was similar to 1 and more potent than 2 , while placement of the OMe group at the ortho position 10 eliminated activity

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