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Literature data supported the potential role of mitochondrial dysfunctions (i.e., altered ATP production) in the onset of CFS symptoms such as fatigue and post exertional malaise (Morris and Maes 2014)

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Biosci Biotechnol Biochem 64:244247

The process of ubiquitination ultimately renders proteins to degradation by the proteasome thereby affecting intracellular protein levels (Popovic et al., 2014)