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In almost all genomes, a large part of these genes is organized as clusters indicating repetitive, species-specific duplications

4.4 Targeting mitochondria autophagy to increase tumor immunity Mitochondrial autophagy, as a core mechanism regulating mitochondrial homeostasis, exerts bidirectional effects in tumor immunity by influencing immune cell function, tumor microenvironment metabolism, and innate immune pathways: It can maintain effector function by clearing damaged mitochondria from immune cells and enhance immune responses by activating the STING pathway

ROS accumulation was evident at 60 mM in U87 and 40 mM in U251, indicating that oxidative stress is a major contributor to Rb-induced cell damage and ferroptosis

Lets back up a bit