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7,8 Moreover, eating a healthy diet, such as the Dietary Approaches to Stop Hypertension (DASH) or Mediterranean diet, and lowering the intake of sodium, phosphorus and sometimes protein may help protect kidney function

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2.3 Key bile acid-sensing receptors modulating the TIME 2.3.1 Farnesoid X receptor: transcriptional control linking metabolism and immunity in the TIME The farnesoid X receptor (FXR, encoded by NR1H4), a nuclear receptor superfamily member, is highly expressed in enterohepatic tissues and various immune cells (e.g., macrophages, DCs, T cells) ( Functionally, FXR-mediated transcription often promotes anti-inflammatory effects and supports immune homeostasis

2.3 Bone marrow-derived macrophage (BMDM) isolation and culture BMDMs were derived from the bone marrow, which was isolated from male C57Bl/6 mice and cultured in DMEM (HyClone) supplemented with 1% penicillin/streptomycin (Invitrogen), 10 ng/mL M-CSF (Peprotech) and 10% FBS (Invitrogen)