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To test this hypothesis, we first treated cells with small molecule inhibitors of pyrimidine and purine metabolism, which generate the ribonucleotide precursors that RNR reduces to dNTPs in a GSH-dependent manner

The GP reaction is: 2GSH + H 2 O 2 GS-SG + 2H 2 O where GSH represents reduced monomeric glutathione, and GS-SG represents glutathione disulfide

Characterization and mapping of DNA damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at nucleotide resolution in human genomic DNA

Alcohol is a gastric irritant that can independently cause nausea, vomiting, gastritis, and diarrhea