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Further, inhibition of TRPM7 activity attenuates RA articular cartilage destruction and chondrocyte ferroptosis by suppressing the PKC-NOX4 axis (129)

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Upon introduction of mushroom TYR (mTYR), cyan-blue fluorescence (ex = 330 nm, em = 470 nm) from the resulted fluorescent triazole (Fluo) was detected immediately (Supplementary Fig

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Notably, phosphorothioates and dithioates are often pro-toxicants, requiring oxidative desulfuration by hepatic cytochrome P450 enzymes to convert into active oxon forms (e.g., parathion paraoxon), which are potent acetylcholinesterase inhibitors

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