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Lowers a signaling protein (TGF-1) and reduces cell stress (measured by an antioxidant enzyme called SOD), both of which contribute to hair follicles shrinking due to the hormone DHT

Tricyclic antidepressants (TCAs) Amitriptyline and nortriptyline: Effective in managing PDPN by inhibiting monoamine reuptake and blocking sodium channels

In the short-term (8 to 9 week) controlled clinical trials of fluoxetine supporting its effectiveness in the treatment of Major Depressive Disorder, patients were administered fluoxetine doses of 10 to 20 mg/day [see Clinical Studies (14.1)]

intensity on a scale of 10 (1 no pain and 10 intolerable pain)