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SIRT1/Nrf2/NF-B signaling mediates anti-inflammatory and anti-apoptotic activities of oleanolic acid in a mouse model of acute hepatorenal damage

In melanoma, PSPH upregulation promotes tumor growth in vitro and in vivo , whereas its knockdown suppresses proliferation (78)

In addition to the well-established extracellular GSH degradation mechanism, studies have shown an additional intracellular hydrolysis pathway for GSH degradation (47,48)