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doi:10.3109/14767058.2011.581713 871. Bozhinovski G, Terzikj M, Kubelka-Sabit K, Plaseska-Karanfilska D

One of these enzymes, HNMT, needs SAM to do its job.2 So, for HNMT to break down histamine properly, its important that the MTHFR enzyme is working well to support this process