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Beginning in 2012, SF-W directed phases of data analysis and made specific requests for data analysis towards finding an integrated theory and requested data in relationship to MTHFR polymorphism activity and the correlation of variables for homocysteine, histamine, elevated Noradrenaline, Adrenaline and Dopamine, % free copper, ceruloplasmin, zinc, vitamin B6, vitamin D, vitamin B12, monoamine oxide activity (NA/MHMA and AD/MHMA), and FMN/FAD availability

A patient may need a strength that isnt commercially availablea higher or lower concentration of a retinoid, a non-standard percentage of hydroquinone, or a steroid potency between two available commercial products

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Dysbiosis and increased intestinal permeability (leaky gut) may amplify neuroinflammatory state of the brain, further justifying the need for research into interventions combining metabolic and microbiota-based therapies