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In addition to the VN, T cells, B cells, dendritic cells (DCs), and macrophages in the follicular and marginal zones of the spleen are other major sources of ACh ( via exocytosis at specialized synaptic clefts ( Figure 1 The relative concentration of ACh in humans is found to be 8 clearance mediated via stimulation of microglial nicotinic acetylcholine receptors

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