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In MS, a condition with autoimmune neuroinflammation, patients often show a microbiome signature that fosters pro-inflammatory T cells (like Th17 cells) at the expense of Tregs [67, 68]

Bumetanide treatment altered the progression of symptoms, as evidenced by significant interaction effects of time group on CARS total score ( t 81 = 9.69, p = 3.46 10 15 ) and number of scores 3 ( t 81 = 5.31, p = 9.38 10 7 ) (Table 2 and Supplementary Fig

Risks and Limitations Handling: BPC-157 should be handled by trained personnel in a controlled research setting, with standard PPE and biosafety protocols

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