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Wang, J., Siddhartha, S., Ghosh, S

CMS is committed to looking holistically at the concerns raised by the commenter across settings of care and will consider how to address for future rulemaking or guidance, and we thank the commenter for continuing to share firsthand experiences

The protein expression of SLC25A39 was evaluated by two independent pathologists who were blinded to the clinical data of the patients

The fact that high levels of peripheral markers of oxidativeinflammatory stress were detected in individuals with MCI lead us to believe that oxidative stress and inflammation are early events in the pathogenesis of AD, and that they precede A deposits and the onset of AD symptoms, which has been shown in experimental models of AD (Ferretti et al., 2012