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Together, these findings position BBB and astrocytic dysfunction as intertwined processes that may amplify neurodegeneration, while underscoring critical gaps, including limited longitudinal human data, uncertain temporal ordering, and the need for integrative multimodal approaches, that must be addressed to determine whether astrocyte, BBB dysfunction drives disease progression or represents a secondary response, and whether it can be targeted for therapeutic intervention

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Compounding and the FDA: Questions and answers