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doi: 10.1111/pim.12193 144 PaceFCarvalhoBMZanottoTMSantosAGuadagniniDSilvaKLCet al

Further research on their mechanisms and therapeutic applications is required

PENNELL D J, CARPENTER J P, ROUGHTON M, et al

Especially, during prolonged passage and culture, cells continuously modulate genes involved in lysosomal function and lipid metabolism, which can lead to an accumulation of reactive oxygen species 46,47