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Cardamonin, a natural chalcone from Alpiniae katsumadai , inhibits breast cancer cell growth by suppressing HIF-1 through blockade of the mTOR pathway and inducing metabolic reprogramming characterized by reduced glucose uptake and lactate transport 191

This indicates that polyP concentration in cardiac myocytes is variable and depends on levels of energy substrates and the degree of coupling of the mitochondrial respiratory chain

This subcellular localization enables the direct protection of mitochondrial lipids, proteins, and mtDNA from oxidative damage, a critical advantage in diseases like neurodegeneration and metabolic disorders

Given that gut microbiota regulate immune function and inflammation, both key features of PTSD pathophysiology, this axis represents a promising therapeutic target