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As expected deletion of either the prothrombin-binding PT domain or the collagen-binding A1 domain significantly reduced thrombin activity on the collagen surface, whereas deletion of the fibrinogen-binding FA domain had minimal effect, highlighting the importance of PT and A1 in thrombin localisation

Goud PT, Bai D, Abu-Soud HM (2021) A multiple-hit hypothesis involving reactive oxygen species and myeloperoxidase explains clinical deterioration and fatality in COVID-19

Choi et al., 2000) and with purified enzyme has been shown to also decrease the K M for glutamate (Huang et al., 1993)

Low Side-Effect Profile Well-tolerated and non-stimulatory