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[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B

DAA and reactive astrocytes in AD Alongside microglia, astrocyte heterogeneity plays a crucial role in AD pathogenesis (Figure 3)

In this regard, it has been shown that tamoxifen, a type of selective estrogen receptor modulator (SERM) that acts as a competitive antagonist or as a partial agonist depending on the cell type, favors the repair of demyelinated lesions in the CNS by increasing the mRNA levels of myelin basic protein (MBP) and 2, 3-Cyclic nucleotide 3-phosphodiesterase (CNP), two genes highly expressed during oligodendroglial differentiation (Gonzalez et al., 2016)

In breast cancer cells, luteolin activates ERK and p38 MAPK pathways, and their inhibition or knockdown reduces luteolin-induced cell death, while caspase-3 inhibition has no effect