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Intriguingly, NADPH-dependent reductive stress stimulated glutaminolysis to generate -KG, which was then converted to succinyl-CoA by oxidative decarboxylation in the TCA cycle or to citrate via IDH2-mediated reductive carboxylation (23)

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3L-N and Supplementary Figure S18, co-transplantation of NFX-treated macrophages with HCC cells significantly inhibited tumor growth

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