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Advanced oxidative protein products produced in SCI rats can promote pyroptosis and inflammation via the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase 4 (NOX4)-ROS-NLRP3-GSDMD pathway and the NOX4-ROS-MAPK-NF-B pathway (Liu et al., 2020b)

Notably, all the listed ESCM are commercially available as drugs or supplements, and thus clarifying their bioactive constituents and corresponding anti-cancer mechanisms can facilitate drug repurposing and dietary health applications

The specific ratio matters less than ensuring adequate amounts of each peptide are delivered per spray