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TMAO is also a significant factor in diabetic kidney disease (DKD) progression, with elevated plasma TMAO levels leading to NLRP3 inflammasome formation and activation in endothelial cells, which then results in endothelial dysfunction, increased monocyte adhesion, and production of pro-inflammatory cytokines in blood vessels, eventually progressing to vascular oxidative stress and DKD

Auch die Grundthesen klingen zunchst logisch Studien zeichnen allerdings ein anderes Bild

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Recently, the International Association for the Study of Pain defined nociplastic pain as pain occurring from an altered nociception in spite of no evidence of any tissue damage (Freynhagen et al., 2019)