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Naringenin inhibits the NLRP3/NF-B pathway in kupffer cells and hepatocytes, reducing lipid deposition and inflammation in NAFLD

Acknowledgements This work was supported by grants from the Singapore Ministry of Education Academic Research Fund (T1-2011 Sep-05 and T1-2014 Apr -05) awarded to YC Long

MtDNA mutations, which accumulate with age due to replication errors and ROS damage exceeding repair capacity [15], are associated with age-related diseases [16, 17]

Together with adaptive treatment paradigms and combination strategies, heterogeneity-focused clinical trials represent a critical step toward operationalizing evolutionary oncology in routine cancer care