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Jones, K

These factors disrupt the delicate balance between the beneficial and harmful roles of lipids, leading to synaptic damage by impairing neurotransmitter release, synaptic plasticity, and membrane stability ( Table 3 )

2.3 Dysregulation of mitophagy The accumulation of fragmented and dysfunctional mitochondria resulting from excessive fission imposes a critical burden on the mitophagic clearance system