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Description

A comparison was performed between the predicted exposure using in silico methods (described in item 2.3) and the measured bioactivity responses (i.e., PoDs as determined using the state-space model approach)

Acute kidney injury model established by systemic glutathione depletion in mice

Injection-site reactions are among the most commonly reported side effects: patients may experience pain, stinging, or mild burning at the IM injection site