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622 NMDA receptor antagonists Dextromethorphan: NMDA receptor antagonists may mitigate central sensitization and enhance descending inhibitory pathways involved in neuropathic pain

The synergy isn't additiveit's multiplicative, provided dosing timing prevents competitive inhibition at the cellular level

In practice since 2010, Dr.Zachar became introduced to Holistic Medicine during his undergraduate years while studying Health Sciences at the University of Central Florida