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When using the ICD-11, symptoms of inattention or symptoms of hyperactivity and impulsivity or a combination of both must persist at least for 6 months before a diagnosis of ADHD is made

This implies that females are more commonly and, possibly, severely affected than males, and, in familial cases, the disease is more frequently transmitted by an affected mother

Consistent with its proposed, exclusive role in the maturation of [4Fe-4S] clusters, ABCB7 deletion has little effect on mitochondrial [2Fe-2S] + protein activity but results in functionally deficient cytosolic and nuclear [4Fe-4S] 2+ proteins ( + cluster ([2Fe-2S](SG) 4 ) is the natural substrate for ABCB7, and is thus, represents the [2Fe-2S] + cluster that is utilized by the CIA machinery ( 2+ cluster formation to occur