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Alternative views are that LB formation is a process for detoxification of pathological Syn aggregates located at a harmful site in the neuron, such as the presynapse [54]

Dysfunctional or uncontrolled inflammation can be characterised as a chronic low-grade inflammation such as that observed in diabetes, obesity and atherosclerosis ( Reference Lloyd-Jones, Adams and Carnethon 1 , Reference Boosalis 2 )

[PubMed] [Google Scholar] 249.Fernandez-Flores A., Nguyen T., Cassarino D.S

employed lentiviral transduction of four human genes (hOCT4, hSOX2, hKLF4, and hc-MYC) commonly used for iPSC generation in mice and humans [83]