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Heat shock protein 90 as a drug target: some like it hot

It also suppresses oxidative stress and inhibits cell and tissue damage

Given that the therapeutic effectiveness of type II PSs is highly dependent on the surrounding oxygen concentration, Wang et al

Under normoxic conditions, p53 directly limits glucose uptake by repressing the transcription of GLUT1 and GLUT4, and induces TIGAR expression, thereby reducing PFK1 activity