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When combined with a PER2-activating agent, this strategy further enhances antitumor efficacy through synergistic cuproptosis induction ( As an emerging oncotherapeutic strategy, cuproptosis-directed therapy holds broad promise for OSCC, and future exploration should therefore reach beyond ionophores and nanomedicines to encompass systematic mining of natural-product libraries for plant-derived cuproptosis inducers, structure-based design of next-generation agents that selectively engage FDX1, DLAT or ATP7B, and rational integration of cuproptosis activators with radiation or cisplatin so as to override canonical resistance pathways

Omeprazole's ability to inhibit acid production by the parietal cell is contributing to a large portion of its effect on protein-bound vitamin B12

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Huh-Lunet-T7 RC cells were kindly provided by Prof