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Moreover, RS004 (Horning et al., 2016) and 4-chloro-3-ethynylpyridine (Sen et al., 2019) were also reported to compete with NAM for binding by covalently linking to Cys165 and Cys159 in the active site of NNMT

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Another 2019 review showed it may help lower total and LDL ("bad") cholesterol while raising HDL ("good") cholesterol in individuals at risk for heart disease