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Beyond classical antioxidant enzymes, dysregulation of multiple OS-related proteins and pathways has been reported in MS, including peroxiredoxin (PRX), an enzyme critical for reducing H 2 O 2 whose dysregulation may impair the cellular ability to handle peroxides (Voigt et al., 2017

Therefore, this narrative review navigates into the intricate role of TRP metabolism in insomnia and its psychological and neurological comorbidities, particularly cognitive dysfunction, depression, anxiety, stress, traumatic brain injury (TBI), chronic pain, and substance abuse

Cadmium, environmental exposure and health outcomes

Foeller E, Feldman DE (2004)