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CAFs serve a dual purpose as essential elements in the TME

In ZnONP-containing media, the highest 5.630.09 mg g -1 FW content was obtained at 2 mg L -1 , whereas callus grown with Zn bulk showed a lower value (4.220.09 mg g -1 FW)

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Recognizing these differences is therefore crucial for optimizing pharmacotherapy and reducing the risk of adverse reactions, particularly in patient populations with altered DME expression, as observed in both rodent and human samples with MASLD and MASLD-associated metabolic comorbidities [108]