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130 PharmaceuticalsS

Understanding this heterogeneity is pivotal for maximizing therapeutic benefit and for containing the substantial drug-acquisition costs that currently limit access

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Activation involves signaling pathways such as JAKSTAT, NF-B, mitogen-activated protein kinase (MAPK) and calcineurin, leading to cytoskeletal changes marked by the upregulation of GFAP, vimentin and nestin 35,44,45