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In recent years, various approaches have been developed to promote induction of MSCs into Schwann-like cells, particularly the use of certain small molecules or growth factors [48, 50] and engineered substrates or scaffolds such as graphene oxide substrate [51], 3D-printed polycaprolactone/polypyrrole (PCL/PPy) conductive scaffold [52], 3D-printed bionic polycaprolactone (PCL) polymer scaffold [53], and aligned nanofibers [54]

So, if the diet is low in nutrients, the skin will suffer first

Loss of the fragile X mental retardation protein decouples metabotropic glutamate receptor dependent priming of long-term potentiation from protein synthesis

Moreover, targeted disruption of MsrA in mice significantly reduced their life span, increased their susceptibility to oxidative stress, and accentuated the accumulation of oxidized proteins in their tissues [202]