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reported that IgA is regulated by acetate through metabolite sensing GPR43

The G6PD enzyme is the rate-limiting step of this pathway

10.1155/2015/843721 101 KaS.LinJ.LinT.LiuF

however, in diabetic states, hyperglycemia activates mitochondrial respiratory pathways, including the sorbitol and polyol pathways, resulting in excessive ROS production