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Molecules that were classified as having a high-risk of DDI by the three databases are other anticoagulants with an additive effect on hemostasis (PD interaction) and strong inhibitors or inducers of the cytochromes and/or Pgp involved in the metabolism of the DOAC and the VKA (i.e., phenytoin, ketoconazole, itraconazole, rifampicin, St Johns wort (Hyperium Perforatum), resulting in a change in drug exposure and, as a consequence, a lack of efficacy or toxicity