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Finally, we generated castration-resistant VCaP cells by switching regularly cultured VCaP cells (DMEM + 20% FBS) to CDSS-containing medium for 1 week followed by treatment with the PROTAC ARv7 degrader-1 (0.5 M, 24 h

Put simply, Philadelphia chromosome, or Ph, is a genetic abnormality in chromosome 22 of leukaemia cancer cells essentially a mutation within an important chromosome that controls RBC production, where a chromosome is a thread-like structure containing your DNA, all tightly packed up and wrapped around proteins called histones