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Adverse Reactions / Side Effects Common (usually mild and self-limited): Flushing Headache Fatigue Nausea Metallic taste Injection-site pain (IV or IM) Rash or pruritus Moderate: Hypotension during IV infusion Diarrhea Dizziness Transient increases in liver enzymes Allergic reactions (urticaria) Serious (require immediate discontinuation): A

Acknowledgements This work was funded by the scientific research project of Hainan Province Science and Technology Special Fund (ZDYF2022SHFZ321, ZDYF2020178), Hainan Provincial Graduate Innovation Research Project (Qhyb2022-49)

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AmB is highly efficacious but also has associated toxicity such as includes fever, nausea, vomiting, rigors, hypertension or hypotension, and hypoxia when administered in its free deoxycholate form which has been overcome in its liposomal formulation (Laniado-Laborn and Cabrales-Vargas, 2009