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Upon implantation, the water soluble binder is absorbed within 24 to 72 hours, creating a 3-dimensional porous scaffold that facilitates diffusion of blood and tissue fluids through the matrix

Other supportive evidence is the correlation of the rate of transport of a given substance with transcellular electrical resistance, in which lower transport rates of substances assumed to be transported paracellularly are observed in high-resistance, tight epithelia, although electrical resistance and the transport of marker molecules do not always coincide