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Aging: a revisited theory based on free radicals generated by NOX family NADPH oxidases

For example, C16-carnitine (10 M) may impair mitochondrial function in rat ventricular myocytes by accelerating ROS production and increasing the probability of mitochondrial permeability transition pore (mPTP) opening, whereas low concentrations (1 and 5 M) of C16-carnitine lightly hyperpolarize the m but do not open the mPTP [293]

Melatonin alone had no effect, and there was little interaction between IF and melatonin except for their effects on adipocyte area and number, the abundance of Bacteroidetes and Akkermansia , and the intestinal metabolites alanine, valine and isoleucine

The assembly/disassembly of the FeS-Trx1 dimer fine tunes the activity of IRP1, a main regulator of iron homeostasis acting on the posttranslational level [13-15]