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10.1111/j.1524-4725.1997.tb00016.x 156 LiuH.LinY.NieX.ChenS.ChenX.ShiB.et al (2011)

If formation of adducts occurs at the N-3 or N-7 of Ade, or the N-7 of Gua, the most nucleophilic sites in Ade and Gua [55], destabilization of the glycosyl bond and subsequent depurination of the adduct from DNA takes place [20, 22, 25]

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3 Once activated by infection, neutrophils are rapidly recruited to sites of inflammation in the lungs, where they produce and secrete cytokines, enzymes, including elastase (NE), reactive oxygen species (ROS) by oxidative burst, and finally release DNA to form neutrophil extracellular traps (NETs)