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At this temperature, degradation slows to nearly imperceptible levels

Nanoparticle microencapsulation-based platforms are exploited for successful delivery of trehalose into small cells, which are often needed in large quantities to avoid cryoinjury [39,40,41]

The results were expressed as lactulose apparent permeability (Papp) calculated with the following formula: Where: C Baso = Concentration of lactulose in the basolateral compartment (mg/L)

As expected, ferroptotic and necroptotic pathways played key roles, as evidenced by reduced levels of various immune cells in the tumor microenvironment (TME) and reduced expression of an early activation marker (CD69) and effector cytokines (IFN- and TNF-) by tumor-infiltrating CD8 + and CD4 + T cells in Acsl4 -/- , Ripk3 -/- and Mlkl -/- mice