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Probably, as a relatively small protein without multi-domains, its unfolding followed a simple path, and it remained active until heat-induced aggregation

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Biochem Pharmacol 33: 29892994 Eck HP, Gmunder H, Hartmann M, Petzoldt D, Daniel V, Droge W (1989) Low concentrations of acidsoluble thiol (cysteine) in the blood plasma of HIV1infected patients