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Lysosomal dysfunction might play an important role in the development of various diseases, including tumors 14,15,16 , neurodegenerative diseases 17,18,19 , inflammatory diseases 20,21,22 , and cardiovascular diseases 23,24,25 (Table 1)

323,324 The influential role of ALOX12, ALOX15, and 12-HETE on diabetes progression is also correlated with NOX (nicotinamide adenine dinucleotide phosphate oxidase)-mediated endoplasmic reticulum stress, TRPV1 activity, and MAPK signaling, ultimately leading to cell apoptosis

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It may also encourage healthy acetyl-coenzyme A levels, which your body uses to produce acetylcholine