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The irony was not lost on clinicians or patients: the FDA restricted access through the most regulated channel while the least regulated channel remained wide open

As an unsupervised statistical method, PCA can simplify the multivariate data into a few principal components, which can highlight intrinsic trends, distribution of clusters and the existence of outliers

Methods Study design and setting Data were obtained from the Netherlands Study of Depression and Anxiety (NESDA), an ongoing naturalistic longitudinal cohort study examining course and consequences of depressive and anxiety disorders