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Heterogeneity within GBM (regional genetic variance and cellular hierarchies often regulated by different CSC niches) is accepted as the basis for resistance to multiple treatments (155, 156)

10.1016/S0014-5793(99)01393-9 20 DelwingD.BavarescoC

Of these, three genes were newly discovered, thus, further follow-up studies are warranted for their functional annotation

In early-stage cancer and precancerous lesions, decreased expression of GPX3 and increased ROS production stimulate oxidative stress in TME, promoting the progression of EMT and cancer development