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Moreover, the BRCA1 loss mutation, like oncogene activation (RAS, NF-B, TGF-), in cancer cells will drive the initiation of metabolic symbiosis phenotype between tumor cells and fibroblasts in both primary and metastatic cancers (226)

Slides were washed three times in Tris buffer and primary antibody dilutions were prepared in antibody diluent (Zytomed Systems, Berlin, Germany), added to each tissue section in a wet chamber and incubated overnight

Triggered by an extrinsic or an intrinsic pathway, caspase-induced PCD culminates with the formation of apoptotic bodies that are eliminated by adjacent phagocytes 74