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People with RLS experience an irresistible urge to move their legs, which is typically accompanied by aching, itching, or crawling sensations

Among these is vitamin B12 (cobalamin) , a water-soluble vitamin crucial for red blood cell formation, neurological function, and DNA synthesis

In a further aspect of the invention, one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy is contacted with a cell expressing NNMT followed by contacting said cell expressing NNMT one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein)

Targeted use before periods of high demand